Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex

The platelet glycoprotein Ib-IX-V complex (GPIb-IX-IV) is the receptor for VWF and is responsible for VWF-mediated platelet activation and aggregation. Loss of the GPIb-IX-V complex is pathogenic for Bernard-soulier Syndrome (BSS), which is characterized by macrothrombocytopenia and impaired platele...

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Bibliographic Details
Main Authors: Staron, Matthew, Wu, Shuang, Hong, Feng, Stojanovic, Aleksandra, Du, Xiaoping, Bona, Robert, Liu, Bei, Li, Zihai
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143555/
https://ncbi.nlm.nih.gov/pubmed/21576699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-330464
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