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Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen

Mice carrying a targeted mutation (r) in Col1a1, encoding a collagenase-resistant form of type I collagen, have altered skeletal remodeling. In hematoxylin and eosin–stained paraffin sections, we detect empty lacunae in osteocytes in calvariae from Col1a1(r/r) mice at age 2 weeks, increasing through...

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Main Authors: Zhao, Weiguang, Byrne, Michael H., Wang, Yingmin, Krane, Stephen M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC314341/
https://ncbi.nlm.nih.gov/pubmed/11032854
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