Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization

Vascular smooth muscle cells (VSMCs) at capacitance arteries of hypertensive individuals and animals undergo marked age- and blood pressure–dependent polyploidization and hypertrophy. We show here that VSMCs at capacitance arteries of rat models of hypertension display high levels of Akt1/PKB protei...

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Pubblicato in:J Clin Invest
Autori principali: Hixon, Mary L., Muro-Cacho, Carlos, Wagner, Mark W., Obejero-Paz, Carlos, Millie, Elise, Fujio, Yasushi, Kureishi, Yasuko, Hassold, Terry, Walsh, Kenneth, Gualberto, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
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Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314338/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11032861/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8252
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