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Differential coreceptor expression allows for independent evolution of non–syncytium-inducing and syncytium-inducing HIV-1

We demonstrated previously that CD45RA(+) CD4(+) T cells are infected primarily by syncytium-inducing (SI) HIV-1 variants, whereas CD45RO(+) CD4(+) T cells harbor both non-SI (NSI) and SI HIV-1 variants. Here, we studied evolution of tropism for CD45RA(+) and CD45RO(+) CD4(+) cells, coreceptor usage...

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Udgivet i:J Clin Invest
Principais autores: van Rij, Ronald P., Blaak, Hetty, Visser, Janny A., Brouwer, Margreet, Rientsma, Ronald, Broersen, Silvia, de Roda Husman, Ana-Maria, Schuitemaker, Hanneke
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314337/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11032864/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7953
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