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Structure of a yeast RNase III dsRBD complex with a non-canonical RNA substrate provides new insights into binding specificity of dsRBDs
DsRBDs often bind dsRNAs with some specificity, yet the basis for this specificity is poorly understood. Rnt1p, the major RNase III in Saccharomyces cerevisiae, cleaves RNA substrates containing hairpins capped by A/uGNN tetraloops, using its dsRBD to recognize the conserved fold of these tetraloops...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143303/ https://ncbi.nlm.nih.gov/pubmed/21742266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.03.022 |
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