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Consequences of Stabilizing the Natively Disordered F helix for the Folding Pathway of Apomyoglobin

The F helix region of sperm whale apomyoglobin (apoMb) is disordered, undergoing conformational fluctuations between a folded helical conformation and one or more locally unfolded states. In order to examine the effects of F helix stabilization on the folding pathway of apoMb, we have introduced mut...

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Bibliographic Details
Main Authors: Nishimura, Chiaki, Dyson, H. Jane, Wright, Peter E.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143293/
https://ncbi.nlm.nih.gov/pubmed/21640124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.05.028
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