Molecular basis of a million-fold affinity maturation process in a protein-protein interaction

Protein engineering is increasingly important for pharmaceutical applications where controlling the specificity and affinity of engineered proteins is required to create targeted protein therapeutics. Affinity increases of several thousand-fold are now routine for a variety of protein engineering ap...

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Bibliographische Detailangaben
Hauptverfasser: Bonsor, Daniel A., Postel, Sandra, Pierce, Brian G., Wang, Ningyan, Zhu, Penny, Buonpane, Rebecca A., Weng, Zhiping, Kranz, David M., Sundberg, Eric J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143254/
https://ncbi.nlm.nih.gov/pubmed/21689661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.009
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