Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)

BACKGROUND: Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer death in the USA. Recurrence rates are high after front-line therapy and most patients eventually die from platinum (Pt) - resistant disease. Cisplatin resistance is associated with increased nucleotide excision r...

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Bibliographic Details
Main Authors: Muenyi, Clarisse S, States, Vanessa A, Masters, Joshua H, Fan, Teresa W, Helm, C William, States, J Christopher
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143084/
https://ncbi.nlm.nih.gov/pubmed/21696631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-4-9
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