Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation

The anaphase-promoting complex or cyclosome (APC/C) is an ubiquitin protein ligase that together with Cdc20 and Cdh1 targets mitotic proteins for degradation by the proteosome. APC–Cdc20 activity during mitosis triggers anaphase by destroying securin and cyclins. APC–Cdh1 promotes degradation of cyc...

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Detalhes bibliográficos
Main Authors: Wirth, Karin G., Ricci, Romeo, Giménez-Abián, Juan F., Taghybeeglu, Shahryar, Kudo, Nobuaki R., Jochum, Wolfram, Vasseur-Cognet, Mireille, Nasmyth, Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC314282/
https://ncbi.nlm.nih.gov/pubmed/14724179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.285404
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