Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression

Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We have created conditional knockout alleles of the mouse Separase and Securin genes. Deletion of both copies of...

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Autores principales: Wirth, Karin G., Wutz, Gordana, Kudo, Nobuaki R., Desdouets, Chantal, Zetterberg, Anders, Taghybeeglu, Shahryar, Seznec, Janina, Ducos, Germain M., Ricci, Romeo, Firnberg, Nicole, Peters, Jan-Michael, Nasmyth, Kim
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2006
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063729/
https://ncbi.nlm.nih.gov/pubmed/16533945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200506119
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