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Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression

Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister chromatid disjunction at anaphase onset in yeast by cleaving cohesin's kleisin subunit. We have created conditional knockout alleles of the mouse Separase and Securin genes. Deletion of both copies of...

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Detalhes bibliográficos
Main Authors: Wirth, Karin G., Wutz, Gordana, Kudo, Nobuaki R., Desdouets, Chantal, Zetterberg, Anders, Taghybeeglu, Shahryar, Seznec, Janina, Ducos, Germain M., Ricci, Romeo, Firnberg, Nicole, Peters, Jan-Michael, Nasmyth, Kim
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063729/
https://ncbi.nlm.nih.gov/pubmed/16533945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200506119
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