Designing phase II trials in cancer: a systematic review and guidance

BACKGROUND: Literature reviews of cancer trials have highlighted the need for better understanding of phase II statistical designs. Understanding the key elements associated with phase II design and knowledge of available statistical designs is necessary to enable appropriate phase II trial design....

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Detalhes bibliográficos
Main Authors: Brown, S R, Gregory, W M, Twelves, C J, Buyse, M, Collinson, F, Parmar, M, Seymour, M T, Brown, J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142813/
https://ncbi.nlm.nih.gov/pubmed/21712822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.235
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