EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer

BACKGROUND: Only 40–70% of metastatic colorectal cancers (mCRCs) with wild-type (WT) KRAS oncogene respond to anti-epidermal growth factor receptor (anti-EGFR) antibody treatment. EGFR amplification has been suggested as an additional marker to predict the response. However, improved methods for bri...

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Detalhes bibliográficos
Main Authors: Ålgars, A, Lintunen, M, Carpén, O, Ristamäki, R, Sundström, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142805/
https://ncbi.nlm.nih.gov/pubmed/21694725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.223
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