Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

BACKGROUND: MicroRNAs (miRNAs) regulate expression of many cancer-related genes through posttranscriptional repression of their mRNAs. In this study we investigate the proto-oncogene MYCN as a target for miRNA regulation. METHODS: A luciferase reporter assay was used to investigate software-predicte...

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Detalles Bibliográficos
Main Authors: Buechner, J, Tømte, E, Haug, B H, Henriksen, J R, Løkke, C, Flægstad, T, Einvik, C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Genetics and Genomics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142803/
https://ncbi.nlm.nih.gov/pubmed/21654684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.220
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