Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma

BACKGROUND: Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggressive metastatic tumours with poor prognosis. Amplification of the MYCN oncogene...

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Autors principals: Henriksen, Jørn R, Haug, Bjørn Helge, Buechner, Jochen, Tømte, Ellen, Løkke, Cecilie, Flaegstad, Trond, Einvik, Christer
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022612/
https://ncbi.nlm.nih.gov/pubmed/21194500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-11-1
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