Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

OBJECTIVE: The role of reactive oxygen species (ROS) and their dissipation in type 1 diabetes pathogenesis have garnered considerable controversy. Our recent work has demonstrated the importance of NADPH oxidase (NOX) activity for type 1 diabetes development and modulating T-cell autoreactivity. We...

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Autors principals: Thayer, Terri C., Delano, Matthew, Liu, Chao, Chen, Jing, Padgett, Lindsey E., Tse, Hubert M., Annamali, Mani, Piganelli, Jon D., Moldawer, Lyle L., Mathews, Clayton E.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142064/
https://ncbi.nlm.nih.gov/pubmed/21715554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1222
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