Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

Drugs that target novel surfaces on the androgen receptor (AR) and/or novel AR regulatory mechanisms are promising alternatives for the treatment of castrate-resistant prostate cancer. The 52 kDa FK506 binding protein (FKBP52) is an important positive regulator of AR in cellular and whole animal mod...

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Bibliografiska uppgifter
Huvudupphovsmän: De Leon, Johanny Tonos, Iwai, Aki, Feau, Clementine, Garcia, Yenni, Balsiger, Heather A., Storer, Cheryl L., Suro, Raquel M., Garza, Kristine M., Lee, Sunmin, Sang Kim, Yeong, Chen, Yu, Ning, Yang-Min, Riggs, Daniel L., Fletterick, Robert J., Guy, R. Kiplin, Trepel, Jane B., Neckers, Leonard M., Cox, Marc B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141981/
https://ncbi.nlm.nih.gov/pubmed/21730179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105160108
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