Compound C Inhibits Vascular Smooth Muscle Cell Proliferation and Migration in an AMP-Activated Protein Kinase-Independent Fashion

6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrazolo[1,5-a] pyrimidine (compound C) is a cell-permeable pyrrazolopyrimidine derivative that acts as a potent inhibitor of AMP-activated protein kinase (AMPK). Although compound C is often used to determine the role of AMPK in various physiolo...

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Autores principales: Peyton, Kelly J., Yu, Yajie, Yates, Benjamin, Shebib, Ahmad R., Liu, Xiao-ming, Wang, Hong, Durante, William
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2011
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141893/
https://ncbi.nlm.nih.gov/pubmed/21566210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.181784
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