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Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for the discovery and development of small-molecule therapeutics, it is posited that additional protein components of the signal transduction pathways emanating from activated GPCRs themselves are attractive as drug...

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מידע ביבליוגרפי
Main Authors: Kimple, Adam J., Bosch, Dustin E., Giguère, Patrick M., Siderovski, David P.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141876/
https://ncbi.nlm.nih.gov/pubmed/21737532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.110.003038
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