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The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern

Developmentally regulated V(D)J recombination profoundly influences immune repertoires, but the underlying mechanisms are poorly understood. In the endogenous T cell receptor Cγ1 cluster, the 3′ Vγ3 gene (closest to Jγ1) rearranges preferentially in the fetal period whereas rearrangement of the 5′ V...

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Bibliografske podrobnosti
Main Authors: Xiong, Na, Baker, Jeanne E., Kang, Chulho, Raulet, David H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC314173/
https://ncbi.nlm.nih.gov/pubmed/14691262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0303738101
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