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The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern
Developmentally regulated V(D)J recombination profoundly influences immune repertoires, but the underlying mechanisms are poorly understood. In the endogenous T cell receptor Cγ1 cluster, the 3′ Vγ3 gene (closest to Jγ1) rearranges preferentially in the fetal period whereas rearrangement of the 5′ V...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314173/ https://ncbi.nlm.nih.gov/pubmed/14691262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0303738101 |
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