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The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern
Developmentally regulated V(D)J recombination profoundly influences immune repertoires, but the underlying mechanisms are poorly understood. In the endogenous T cell receptor Cγ1 cluster, the 3′ Vγ3 gene (closest to Jγ1) rearranges preferentially in the fetal period whereas rearrangement of the 5′ V...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14691262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0303738101 |
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