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Hybridoma-free generation of monoclonal antibodies

Production of monoclonal antibodies requires immortalization of splenocytes by somatic fusion to a myeloma cell line partner (hybridomas). Although hybridomas can be immortal, they may depend on a feeder cell layer and may be genetically unstable. Since the inception of hybridoma technology, efforts...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pasqualini, Renata, Arap, Wadih
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314172/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14688405/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305834101
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