An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

BACKGROUND: In vitro cell systems together with omics methods represent promising alternatives to conventional animal models for toxicity testing. Transcriptomic and proteomic approaches have been widely applied in vitro but relatively few studies have used metabolomics. Therefore, the goal of the p...

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Hauptverfasser: Ruiz-Aracama, Ainhoa, Peijnenburg, Ad, Kleinjans, Jos, Jennen, Danyel, van Delft, Joost, Hellfrisch, Caroline, Lommen, Arjen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141663/
https://ncbi.nlm.nih.gov/pubmed/21599895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-251
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