Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been demonstrated to develop enhanced inflammation and progressive neurodegeneration. Loss of function mutations of the PGRN gene have been...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Bossù, Paola, Salani, Francesca, Alberici, Antonella, Archetti, Silvana, Bellelli, Giuseppe, Galimberti, Daniela, Scarpini, Elio, Spalletta, Gianfranco, Caltagirone, Carlo, Padovani, Alessandro, Borroni, Barbara
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Short Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141503/
https://ncbi.nlm.nih.gov/pubmed/21645364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-65
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki