Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been demonstrated to develop enhanced inflammation and progressive neurodegeneration. Loss of function mutations of the PGRN gene have been...

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Bibliographische Detailangaben
Hauptverfasser: Bossù, Paola, Salani, Francesca, Alberici, Antonella, Archetti, Silvana, Bellelli, Giuseppe, Galimberti, Daniela, Scarpini, Elio, Spalletta, Gianfranco, Caltagirone, Carlo, Padovani, Alessandro, Borroni, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141503/
https://ncbi.nlm.nih.gov/pubmed/21645364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-65
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