Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ(null )mice after polyclonal B cell reconstitution

BACKGROUND: Non Obese Diabetic mice lacking B cells (NOD.Igμ(null )mice) do not develop diabetes despite their susceptible background. Upon reconstitution of B cells using a chimera approach, animals start developing diabetes at 20 weeks of age. METHODS: We have used the spectratyping technique to f...

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Detalhes bibliográficos
Main Authors: Vong, Allen M, Daneshjou, Nazila, Norori, Patricia Y, Sheng, Huiming, Braciak, Todd A, Sercarz, Eli E, Gabaglia, Claudia Raja
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141497/
https://ncbi.nlm.nih.gov/pubmed/21722394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-101
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