Vascular Calcification and Aortic Fibrosis: A Bifunctional Role for Osteopontin In Diabetic Arteriosclerosis

OBJECTIVE: Calcification and fibrosis reduce vascular compliance in arteriosclerosis. To better understand the role of osteopontin (OPN), a multifunctional protein upregulated in diabetic arteries, we evaluated contributions of OPN in male LDLR−/− mice fed high fat diets (HFD). METHODS AND RESULTS:...

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Hlavní autoři: Shao, Jian-Su, Sierra, Oscar L., Cohen, Richard, Mecham, Robert P., Kovacs, Attila, Wang, James, Distelhorst, Kathryn, Behrmann, Abraham, Halstead, Linda R., Towler, Dwight A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141097/
https://ncbi.nlm.nih.gov/pubmed/21597007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.230011
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