A Novel Redox Method for Rapid Production of Functional Bi-Specific Antibodies For Use in Early Pilot Studies

We demonstrate here a rapid alternative method for the production of functional bi-specific antibodies using the mild reducing agent 2-mercaptoethanesulfonic acid sodium salt (MESNA). Following reduction of a mixture of two monoclonal antibodies with MESNA to break inter heavy chain bonds, this solu...

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Bibliographic Details
Main Authors: Carlring, Jennifer, De Leenheer, Evy, Heath, Andrew William
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141073/
https://ncbi.nlm.nih.gov/pubmed/21811628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022533
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