Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis

BACKGROUND: Evaluation of cystic fibrosis transmembrane conductance regulator (CFTR) functional activity to assess new therapies and define diagnosis of cystic fibrosis (CF) is cumbersome. It is known that leukocytes express detectable levels of CFTR but the molecule has not been characterized in th...

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Main Authors: Sorio, Claudio, Buffelli, Mario, Angiari, Chiara, Ettorre, Michele, Johansson, Jan, Vezzalini, Marzia, Viviani, Laura, Ricciardi, Mario, Verzè, Genny, Assael, Baroukh Maurice, Melotti, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141019/
https://ncbi.nlm.nih.gov/pubmed/21811577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022212
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