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Dramatic destabilization of transmembrane helix interactions by features of natural membrane environments
Membrane proteins have evolved to fold and function in a lipid bilayer, so it is generally assumed that their stability should be optimized in a natural membrane environment. Yet optimal stability is not always in accord with optimization of function, so evolutionary pressure, occurring in a complex...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140635/ https://ncbi.nlm.nih.gov/pubmed/21682279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204524c |
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