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Dramatic destabilization of transmembrane helix interactions by features of natural membrane environments

Membrane proteins have evolved to fold and function in a lipid bilayer, so it is generally assumed that their stability should be optimized in a natural membrane environment. Yet optimal stability is not always in accord with optimization of function, so evolutionary pressure, occurring in a complex...

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Detalhes bibliográficos
Main Authors: Hong, Heedeok, Bowie, James U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140635/
https://ncbi.nlm.nih.gov/pubmed/21682279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204524c
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