p16(INK4A) Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1

BACKGROUND: The cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and their functional interplay are still not well d...

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Detalhes bibliográficos
Main Authors: Al-Khalaf, Huda H., Colak, Dilek, Al-Saif, Maher, Al-Bakheet, Albandary, Hendrayani, Siti-Faujiah, Al-Yousef, Nujoud, Kaya, Namik, Khabar, Khalid S., Aboussekhra, Abdelilah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140473/
https://ncbi.nlm.nih.gov/pubmed/21799732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021111
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