Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer

Estrogen independence and progression to a metastatic phenotype are hallmarks of therapeutic resistance and mortality in breast cancer patients. Metastasis has been associated with chemokine signaling through the SDF-1–CXCR4 axis. Thus, the development of estrogen independence and endocrine therapy...

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Detalhes bibliográficos
Main Authors: Rhodes, Lyndsay V., Short, Sarah P., Neel, Nicole F., Salvo, Virgilio A., Zhu, Yun, Elliott, Steven, Wei, Yongkun, Yu, Dihua, Sun, Menghong, Muir, Shannon E., Fonseca, Juan P., Bratton, Melyssa R., Segar, Chris, Tilghman, Syreeta L., Sobolik-Delmaire, Tammy, Horton, Linda W., Zaja-Milatovic, Snjezana, Collins-Burow, Bridgette M., Wadsworth, Scott, Beckman, Barbara S., Wood, Charles E., Fuqua, Suzanne A., Nephew, Kenneth P., Dent, Paul, Worthylake, Rebecca A., Curiel, Tyler J., Hung, Mien-Chie, Richmond, Ann, Burow, Matthew E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140407/
https://ncbi.nlm.nih.gov/pubmed/21123450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3185
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