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Differential cardiotoxic/cardioprotective effects of β-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy

β-Adrenoceptor (β-AR) subtypes act through different signaling pathways to regulate cardiac function and remodeling. Previous in vivo data show a markedly enhanced cardiotoxic response to doxorubicin in β2−/− mice, which is rescued by the additional deletion of the β1-AR. We determined whether this...

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Main Authors: Fajardo, Giovanni, Zhao, Mingming, Powers, Jennifer, Bernstein, Daniel
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140223/
https://ncbi.nlm.nih.gov/pubmed/16458323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2005.12.004
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