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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
The Raf kinase family serves as a central intermediate to relay signals from Ras to ERK. The precise molecular mechanism for Raf activation is still not fully understood. Here we report that phosphorylation of Thr598 and Ser601, which lie between kinase subdomains VII and VIII, is essential for B-Ra...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314015/ https://ncbi.nlm.nih.gov/pubmed/11032810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.20.5429 |
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