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The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

The ubiquitin protein ligase SCF(Skp2) is composed of Skp1, Cul1, Roc1/Rbx1 and the F-box protein Skp2, the substrate-recognition subunit. Levels of Skp2 decrease as cells exit the cell cycle and increase as cells re-enter the cycle. Ectopic expression of Skp2 in quiescent fibroblasts causes mitogen...

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Udgivet i:EMBO J
Principais autores: Wirbelauer, Christiane, Sutterlüty, Hedwig, Blondel, Marc, Gstaiger, Mathias, Peter, Matthias, Reymond, Francoise, Krek, Wilhelm
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314004/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11032804/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.20.5362
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