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Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 Å and the human p70 complex at 2.8 Å resolution, which reveals that IL-12 is similar to class 1 cytokine–rece...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC313992/ https://ncbi.nlm.nih.gov/pubmed/10899108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.14.3530 |
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