Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and its structure-activity relationships

Isothiocyanates (ITCs) derived from cruciferous vegetables induce apoptosis in cancer cells. We demonstrate that certain naturally-occurring ITCs selectively deplete mutant p53, but not the wild type, and do so via a transcription-independent mechanism. Direct p53 binding followed by conformational...

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Hauptverfasser: Wang, Xiantao, Di Pasqua, Anthony J., Govind, Sudha, McCracken, Erin, Hong, Charles, Mi, Lixin, Mao, Yuehua, Wu, Jessie Yu-Chieh, Tomita, York, Woodrick, Jordan C., Fine, Robert L., Chung, Fung-Lung
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139710/
https://ncbi.nlm.nih.gov/pubmed/21241062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101199t
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