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Dynamics of Preferential Substrate Recognition in HIV-1 Protease: Redefining the Substrate Envelope
HIV-1 protease (PR) permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. Though HIV-1 PR inhibitors (PIs) are used in combination antiviral therapy, the emergence of drug resistance has limited their efficacy. The rapid evolution of HIV-1 necessitates the consideration of dru...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139114/ https://ncbi.nlm.nih.gov/pubmed/21762811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.053 |
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