Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11

CYP102A1, originating from Bacillus megaterium, is a highly active enzyme which has attracted much attention because of its potential applicability as a biocatalyst for oxidative reactions. Previously we developed drug-metabolizing mutant CYP102A1 M11 by a combination of site-directed and random mut...

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Détails bibliographiques
Auteurs principaux: Vottero, Eduardo, Rea, Vanina, Lastdrager, Jeroen, Honing, Maarten, Vermeulen, Nico P. E., Commandeur, Jan N. M.
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2011
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139092/
https://ncbi.nlm.nih.gov/pubmed/21567268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-011-0789-4
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