CYP3A5, ABCB1 and SLCO1B1 Polymorphisms and Pharmacokinetics and Virologic Outcome of Lopinavir/Ritonavir in HIV-infected Children

OBJECTIVE: CYP3A5, MDR1 (ABCB1) and OATP1 (SLCO1B1) polymorphisms have been associated with variability in the pharmacokinetics (PK) of protease inhibitors. The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (C3435T and G2677T), and SLCO1B1 (T521C and A388AG) polymorphism...

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Main Authors: Rakhmanina, Natella Y., Neely, Michael, Van Schaik, Ron H.N., Gordish-Dressman, Heather, Williams, Keetra D., Soldin, Steven J., van den Anker, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139013/
https://ncbi.nlm.nih.gov/pubmed/21743379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e318225384f
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