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Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

Aberrant forms of the anaplastic lymphoma kinase (ALK) have been implicated in the pathogenesis of multiple human cancers, where ALK represents a rational therapeutic target in these settings. In this study, we report the identification and biological characterization of X-376 and X-396, two potent...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Lovly, Christine M., Heuckmann, Johannes M., de Stanchina, Elisa, Chen, Heidi, Thomas, Roman K., Liang, Chris, Pao, William
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138877/
https://ncbi.nlm.nih.gov/pubmed/21613408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3879
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