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Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo
The bacterial enzyme chondroitinase ABC (ChABC), which cleaves chondroitin sulfate glycosaminoglycan chains, can degrade inhibitory scar tissue formed following spinal cord injury, thereby promoting axonal growth and regeneration. However, delivering the active enzyme for prolonged periods presents...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138860/ https://ncbi.nlm.nih.gov/pubmed/21600922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2011.05.007 |
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