Randomized Multicenter Trial of the Effects of Melanoma-Associated Helper Peptides and Cyclophosphamide on the Immunogenicity of a Multipeptide Melanoma Vaccine

PURPOSE: This multicenter randomized trial was designed to test whether melanoma-associated helper peptides augment CD8(+) T-cell responses to a melanoma vaccine and whether cyclophosphamide (CY) pretreatment augments CD4(+) or CD8(+) T-cell responses to that vaccine. PATIENTS AND METHODS: In all, 1...

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Autori principali: Slingluff, Craig L., Petroni, Gina R., Chianese-Bullock, Kimberly A., Smolkin, Mark E., Ross, Merrick I., Haas, Naomi B., von Mehren, Margaret, Grosh, William W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2011
Soggetti:
Original Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138719/
https://ncbi.nlm.nih.gov/pubmed/21690475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.33.8053
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