Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P(2) between distinct membrane pools

We have previously shown that PIP5KIβ and PIP5KIγ generate functionally distinct pools of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] important for antigen-stimulated Ca(2+) entry in mast cells. In the present study, we find that association of the endoplasmic reticulum (ER) Ca(2+) senso...

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Bibliografiske detaljer
Main Authors: Calloway, Nathaniel, Owens, Tristan, Corwith, Kathryn, Rodgers, William, Holowka, David, Baird, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138702/
https://ncbi.nlm.nih.gov/pubmed/21750194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.084178
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