Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

IL-21 is a proinflammatory cytokine produced by Th17 cells. Abrogation of IL-21 signaling has recently been shown to reduce GVHD while retaining graft-versus-leukemia/lymphoma (GVL) responses. However, the mechanisms by which IL-21 may lead to a separation of GVHD and GVL remain incompletely underst...

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Main Authors: Hanash, Alan M., Kappel, Lucy W., Yim, Nury L., Nejat, Rebecca A., Goldberg, Gabrielle L., Smith, Odette M., Rao, Uttam K., Dykstra, Lindsay, Na, Il-Kang, Holland, Amanda M., Dudakov, Jarrod A., Liu, Chen, Murphy, George F., Leonard, Warren J., Heller, Glenn, van den Brink, Marcel R. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138694/
https://ncbi.nlm.nih.gov/pubmed/21596854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-294785
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