The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients

Glucocorticoid receptor (GR) agonists increase erythropoiesis in vivo and in vitro. To clarify the effect of the dominant negative GRβ isoform (unable to bind STAT-5) on erythropoiesis, erythroblast (EB) expansion cultures of mononuclear cells from 18 healthy (nondiseased) donors (NDs) and 16 patien...

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Autores principales: Varricchio, Lilian, Masselli, Elena, Alfani, Elena, Battistini, Angela, Migliaccio, Giovanni, Vannucchi, Alessandro Maria, Zhang, Wenyong, Rondelli, Damiano, Godbold, James, Ghinassi, Barbara, Whitsett, Carolyn, Hoffman, Ronald, Migliaccio, Anna Rita
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138692/
https://ncbi.nlm.nih.gov/pubmed/21355091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-296921
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