Small nucleolar RNAs U32a, U33 and U35a are critical mediators of metabolic stress

Lipotoxicity is a metabolic stress response implicated in the pathogenesis of diabetes complications and has been shown to involve lipid-induced oxidative stress. To elucidate the molecular mechanisms of lipotoxicity, we used retroviral promoter trap mutagenesis to isolate a cell line that is resist...

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Détails bibliographiques
Auteurs principaux: Michel, Carlos I., Holley, Christopher L., Scruggs, Benjamin S., Sidhu, Rohini, Brookheart, Rita T., Listenberger, Laura L., Behlke, Mark A., Ory, Daniel S., Schaffer, Jean E.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138526/
https://ncbi.nlm.nih.gov/pubmed/21723502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.04.009
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