Protective Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor against Increased β Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes

Chronic exposure to high glucose and fatty acid levels caused by dietary sugar and fat intake induces β cell apoptosis, leading to the exacerbation of type 2 diabetes. Oleic acid and linoleic acid are two major dietary fatty acids, but their effects in diabetes are unclear. We challenged β cell-spec...

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Detalhes bibliográficos
Main Authors: Shirakawa, Jun, Amo, Kikuko, Ohminami, Hirokazu, Orime, Kazuki, Togashi, Yu, Ito, Yuzuru, Tajima, Kazuki, Koganei, Megumi, Sasaki, Hajime, Takeda, Eiji, Terauchi, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138313/
https://ncbi.nlm.nih.gov/pubmed/21613229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217216
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