Proteomics, Ultrastructure, and Physiology of Hippocampal Synapses in a Fragile X Syndrome Mouse Model Reveal Presynaptic Phenotype

Fragile X syndrome (FXS), the most common form of hereditary mental retardation, is caused by a loss-of-function mutation of the Fmr1 gene, which encodes fragile X mental retardation protein (FMRP). FMRP affects dendritic protein synthesis, thereby causing synaptic abnormalities. Here, we used a qua...

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Bibliografiske detaljer
Main Authors: Klemmer, Patricia, Meredith, Rhiannon M., Holmgren, Carl D., Klychnikov, Oleg I., Stahl-Zeng, Jianru, Loos, Maarten, van der Schors, Roel C., Wortel, Joke, de Wit, Heidi, Spijker, Sabine, Rotaru, Diana C., Mansvelder, Huibert D., Smit, August B., Li, Ka Wan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138307/
https://ncbi.nlm.nih.gov/pubmed/21596744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210260
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