Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols

Polycyclic aromatic hydrocarbons (PAH) are environmental and tobacco carcinogens. Metabolic activation of intermediate PAH trans-dihydrodiols by aldo-keto reductases (AKRs) leads to the formation of electrophilic and redox-active o-quinones. We investigated whether O-methylation by human recombinant...

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Autors principals: Zhang, Li, Jin, Yi, Chen, Mo, Huang, Meng, Harvey, Ronald G., Blair, Ian A., Penning, Trevor M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138279/
https://ncbi.nlm.nih.gov/pubmed/21622560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240739
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